Analysis of the Antioxidant and Anticancer Bioactivity of Gamal Plants with Basic In Silico Methods
ANALISIS BIOAKTIVITAS ANTIOKSIDAN DAN ANTIKANKERTANAMAN GAMAL METODE IN SILICO DASAR
Keywords:
antioxidant, anticancer, Gliricidiasepium, in silicoAbstract
In silico research has been carried out to analyze the antioxidant and anticancer bioactivity of the Gliricidiasepium plant. The software used includes knapsackfamily, pubchem, chemdraw, swissadme, passonline and MS excel. The result is that all compounds in the Gliricidia sepium plant have antioxidant and anticancer probability values above 0.500. Sepinol has the highest probability value of 0.873 for antioxidant, 0.869 for free radical scavenger, 0.784 for anticarcinogenic and 0.745 for chemopreventive. As for TP53, the strongest expression enhancer is robinetin with a probability value of 0.920.
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Daina, A., Michielin, O., & Zoete, V. (2017). SwissADME: a free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules. Scientific Reports, 7(1), 42717. https://doi.org/10.1038/srep42717
Iskandar, D., Widodo, N., Warsito, W., Masruri, M., Rollando, R., Warsidah, W., & Antang, Y. P. P. (2022). Proposed Functional Activity of Bioactive Compounds from Spatholobus littoralis Hassk in LC-MS-MS and Silico Studies. Materials Science Forum, 1061, 181–186. https://doi.org/10.4028/p-0uei8m
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Oviyanti, Fitri ; Syarifah, S. H., & Nurul. (2016). Pengaruh Pemberian Pupuk Organik Cair Daun Gamal (Gliricidia Sepium (Jacq.) Kunth Ex Walp.) Terhadap Pertumbuhan Tanaman Sawi (Brassica Juncea L.). Jurnal Biota, 2(1), 61–67. https://jurnal.radenfatah.ac.id/index.php/biota/article/view/531
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Singh, N., Vayer, P., Tanwar, S., Poyet, J.-L., Tsaioun, K., & Villoutreix, B. O. (2023). Drug discovery and development: introduction to the general public and patient groups. Frontiers in Drug Discovery, 3. https://doi.org/10.3389/fddsv.2023.1201419
Alamu, E., Adesokan, M., Fawole, S., Maziya-Dixon, B., Mehreteab, T., & Chikoye, D. (2023). Gliricidia sepium (Jacq.) Walp Applications for Enhancing Soil Fertility and Crop Nutritional Qualities: A Review. Forests, 14, 635. https://doi.org/10.3390/f14030635
Ambrosino, L., Tangherlini, M., Colantuono, C., Esposito, A., Sangiovanni, M., Miralto, M., Sansone, C., & Chiusano, M. L. (2019). Bioinformatics for Marine Products: An Overview of Resources, Bottlenecks, and Perspectives. In Marine Drugs (Vol. 17, Issue 10). https://doi.org/10.3390/md17100576
Bhandari, A., Kalotra, S., Bajaj, P., Sunkaria, A., & Kaur, G. (2022). Dietary intervention with Tinospora cordifolia improved aging-related decline in locomotor coordination and cerebellar cell survival and plasticity in female rats. Biogerontology, 23(6), 809–824. https://doi.org/10.1007/s10522-022-09975-w
Christina, Y., Nafisah, W., Fitri Atho’illah, M., Rifa’i, M., Widodo, N., Djati, M., & Garrido, G. (2021). Anti-breast cancer potential activity of Phaleria macrocarpa (Scheff.) Boerl. leaf extract through in silico studies. Journal of Pharmacy & Pharmacognosy Research, 9, 824–845. https://doi.org/10.56499/jppres21.1092_9.6.824
Daina, A., Michielin, O., & Zoete, V. (2017). SwissADME: a free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules. Scientific Reports, 7(1), 42717. https://doi.org/10.1038/srep42717
Iskandar, D., Widodo, N., Warsito, W., Masruri, M., Rollando, R., Warsidah, W., & Antang, Y. P. P. (2022). Proposed Functional Activity of Bioactive Compounds from Spatholobus littoralis Hassk in LC-MS-MS and Silico Studies. Materials Science Forum, 1061, 181–186. https://doi.org/10.4028/p-0uei8m
Khairunanissa Khairunanissa, Akhmad Rizali, N. K. (2019). Aplikasi Pupuk Organik Cair Daun Gamal Menggunakan Trichoderma Harzianum Terhadap Pertumbuhan Dan Hasil Tanaman Terung Ungu. Agroekotek View, 2(3), 24–29. https://doi.org/https://doi.org/10.20527/agtview.v2i3.1215
Kim, S., Chen, J., Cheng, T., Gindulyte, A., He, J., He, S., Li, Q., Shoemaker, B. A., Thiessen, P. A., Yu, B., Zaslavsky, L., Zhang, J., & Bolton, E. E. (2021). PubChem in 2021: new data content and improved web interfaces. Nucleic Acids Research, 49(D1), D1388–D1395. https://doi.org/10.1093/nar/gkaa971.
Krasnov, A., Barnabas, S. J., Boehme, T., Boyer, S. K., & Weber, L. (2024). Comparing software tools for optical chemical structure recognition. Digital Discovery. https://doi.org/10.1039/D3DD00228D
Limpo, S. Y. (2020). Keputusan Menteri Pertanian Republik Indonesia. https://hortikultura.pertanian.go.id/wp-content/uploads/2020/06/Kepmentan-104-tahun-2020-komoditas-Binaan-Kementan.pdf
Nakamura, Y., Mochamad Afendi, F., Kawsar Parvin, A., Ono, N., Tanaka, K., Hirai Morita, A., Sato, T., Sugiura, T., Altaf-Ul-Amin, M., & Kanaya, S. (2014). KNApSAcK Metabolite Activity Database for Retrieving the Relationships Between Metabolites and Biological Activities. Plant and Cell Physiology, 55(1), e7–e7. https://doi.org/10.1093/pcp/pct176
Nartey, E., Addai, F., Arthur, S., & Bawah, E. (2023). Effect of Gliricidia Sepium Leafy Biomass And Npk (15:15:15) Fertiliser On The Growth And Yield Of Tomato, Solanum Lycopersicum (L.). Journal of Applied Life Sciences and Environment, 56, 273–288. https://doi.org/10.46909/alse-562100
Oviyanti, Fitri ; Syarifah, S. H., & Nurul. (2016). Pengaruh Pemberian Pupuk Organik Cair Daun Gamal (Gliricidia Sepium (Jacq.) Kunth Ex Walp.) Terhadap Pertumbuhan Tanaman Sawi (Brassica Juncea L.). Jurnal Biota, 2(1), 61–67. https://jurnal.radenfatah.ac.id/index.php/biota/article/view/531
Purna Singh, A., Vadakedath, S., & Kandi, V. (2023). Clinical Research: A Review of Study Designs, Hypotheses, Errors, Sampling Types, Ethics, and Informed Consent. Cureus, 15(1), e33374. https://doi.org/10.7759/cureus.33374
Singh, N., Vayer, P., Tanwar, S., Poyet, J.-L., Tsaioun, K., & Villoutreix, B. O. (2023). Drug discovery and development: introduction to the general public and patient groups. Frontiers in Drug Discovery, 3. https://doi.org/10.3389/fddsv.2023.1201419
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